After an even contest in the early stages of the game, UJ drew first blood when Johan Esterhuizen crossed the line.
They maintained the pressure for Curtley Adams to score their second try, giving them an 18-0 lead at halftime.
The Ikey Tigers came out fighting in the second half to open their scoring with a try by Gerard Pieterse.
However, UJ stayed in control, scoring three more tries in the second half to run out comfortable winners.
In Bloemfontein, UP-Tuks ran in nine tries to outclass Shimlas 65-19.
The visitors’ backline were in top form, consistently breaking through the Free Staters’ defence to lead 23-0 after just 21 minutes.
They continued to dominate the first half and a further two tries saw them go into the break 37-0 ahead.
Shimlas eventually opened their score 49 minutes into the game when winger Vuyani Maqina crossed for a try. They added two more tries, but Tuks stayed in charge until the final whistle for a crushing win.
Wits showed their potential when they defeated NMMU-Madibaz 30-20 in their clash in Johannesburg.
The match was extremely tight in the first half, with the fortunes fluctuating to and fro, reflected in the halftime score of 17-17.
After the break Madibaz could earn only three points from the boot of flyhalf Thomas Kean, while Wits scored a try and added two penalties and a conversion to secure an important win.
In the remaining match of the evening, NWU-Pukke overcame a spirited performance by Central University of Technology, winning 43-38.