It will be clash of the only two unbeaten sides in the competition, with the Nelson Mandela University outfit heading the log.
They have 15 points from three games, while their KZN rivals have 10 points from two games, having had a bye last week.
Madibaz coach Jarryd Buys is expecting a different challenge in Maritzburg.
“Unlike some of the other teams I believe UKZN will be a lot more structured,” he said.
“It’s probably fairly similar to the way we play, so we will have to be on the mark in all facets of the game.”
He added that three wins from three matches meant nothing at this stage of the season.
“Nobody in this team is under any illusions about what lies ahead and we haven’t accomplished anything yet.
“I am a big believer in the fact that you play with confidence but you never underestimate any of the opposition. Because that’s when you start slipping up.”
Nonetheless, Buys was satisfied that the hard labour they had put in during the pre-season training was starting to bear fruit.
“We have spent a lot of time on certain aspects and the guys are starting to get their communication right,” he said.
Madibaz Rugby manager Theresa le Roux said the spirit in the team had been a significant factor in their success.
“This has been outstanding because they also do things off the field to build on the team spirit,” she said. “They are starting to gel as a team.”
She also had praise for the coaching team of Buys, Trichardt van Tonder and Zuko Ndlela.
“They form an excellent trio, with fresh ideas. They are also very strict on discipline for all the players, not only on the field but also on the academic front.”