Due to a revamp last year, the Nelson Mandela University outfit will play their first game at Madibaz Stadium since 2016 when they take on University of Cape Town at 4.45pm.
Having overcome a series of injuries to secure his place in the squad, Esterhuizen said he was honoured to take on the role of captain.
“I understand there is an extra responsibility but I’m happy to represent my team in any form,” he said.
“I’ve only played Varsity Cup in 2016 due to injuries, but fortunately I’ve learnt some valuable lessons from the previous years.”
He added that the squad had a strong group of senior players capable of providing leadership, while their younger players were ready for the task ahead.
“From a technical point of view I think we have the ability to play an expansive game.
“We’ll hope to use that strength against our opponents, who are traditionally bigger than us. It will also allow us to play an attractive brand of rugby.”
Esterhuizen said he knew they would have to be at their best against UCT, who lost their first game to Wits on Monday.
“UCT will try and put us under immense pressure by being in our faces on defence,” he said.